Findings by Border and Noble with overexpression of TGF-β1 in renal fibrosis and successful use of neutralizing anti-TGF-β1 antibody demonstrated that the cytokine TGF-β1 plays as a major role in kidney fibrosis during acute anti-thy1 glomerulonephritis [5]. The gene discussed is TGFB1; the disease is glomerulonephritis.