HBEGF and Ventriculomegaly: This experiment has determined that the human HB-EGF reporter, lacZ/β gal, is localized along the tangential migration from the SVZ to the OB in the control animals, while the HB-EGF reporter is widely distributed in the extra-SVZ throughout the cortical layers of the homozygous animal brain in the presence of ventriculomegaly.