HLA-DRB1 and laryngotracheoesophageal cleft: Of the SNPs reported in HBV-related HCC GWASs, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1, and rs9275319 near HLA-DQ were found to be significantly associated with the risk for HBV-related LC [46], suggesting that gene variants associated with HBV-related hepatocarcinogenesis may already play an important role in the progression from CHB to LC.