A meta-analysis [62], including 774 potentially relevant articles and a total of 2308 subjects (1215 responders, 873 nonresponders, and 220 control populations) and assessing the effect of HLA on immunological response to hepatitis B vaccines in healthy individuals, showed that, for DRB1 alleles, the three HLA variants DRB1 ∗01, DRB1 ∗1301, and DRB1 ∗15 are associated with significantly increased antibody response to hepatitis B vaccines, with pooled ORs of 2.73, 5.94, and 2.29, respectively. The gene discussed is HLA-DRB1; the disease is hepatitis B virus infection.