Genome-wide ChIP/chip analysis using wild type Hepa-1c1c7 mouse hepatocellular carcinoma cells and its AhR-deficient c37 derivative, have identified gene clusters regulated by AhR with a suspected implication in cell differentiation, patterning and development under basal cell conditions (Sartor et al., 2009). This evidence concerns the gene AHR and hepatocellular carcinoma.