Importantly, the AhR/ARNT heterodimer and Slug/Snai2 were co-recruited under basal and ligand-induced conditions to B1-X35S elements located in the promoter of developmental and differentiation-related genes Lpp (cell-adhesion related lipoma preferred partner), Tbc1d1 (Obesity risk gene), and Dad1 (Defender against cell death 1) (Roman et al., 2008). This evidence concerns the gene DAD1 and obesity due to melanocortin 4 receptor deficiency.