Importantly, the AhR/ARNT heterodimer and Slug/Snai2 were co-recruited under basal and ligand-induced conditions to B1-X35S elements located in the promoter of developmental and differentiation-related genes Lpp (cell-adhesion related lipoma preferred partner), Tbc1d1 (Obesity risk gene), and Dad1 (Defender against cell death 1) (Roman et al., 2008). Here, SNAI2 is linked to obesity due to melanocortin 4 receptor deficiency.