KMT2A and acute lymphoblastic leukemia: Interestingly, three recent reports suggest a prognostic role for HOXA9 in ETP-ALL: a subset of T-ALL patients enrolled in AALL00434 was analyzed, and the authors concluded that patients with the combination of MLL-rearrangement, high HOXA9 expression, and ETP-ALL (by expression profiling) had a significantly worse outcome (44).