Besides changes in glycan sialylation, which interferes with galectin-3-binding as discussed above, cancer cells often present a significant increase in beta1–6 branching in N-linked glycans due to increased MGAT5 (UDP-N-acetyl-d-glucosamine: N-acetylglucosamine transferase V) activity (81, 82). The gene discussed is LGALS3; the disease is cancer.