In human tongue cancer cell lines as well as pancreatic cell lines, the reduction of migration and invasion leads to a decrease in β-catenin, phospho-Akt, GSK-3β, and some MMP levels, indicating that galectin-3-mediated migration and invasion involves β-catenin degradation initiated by Akt phosphorylation in this model (118). Here, AKT1 is linked to tongue cancer.