The objectives of the present study were (a) to determine a cutoff value of ADC for the differentiation of malignant, benign, and healthy breast tissues in a large cohort of subjects; (b) to evaluate the potential of quantitative DWI in differentiating various histological types of malignant and benign lesions; (c) to evaluate the potential of ADC in indeterminate DCEMRI findings in a sub-group of patients; and (d) to examine the association of ADC, stage, tumor volume, age, menopausal status, and hormonal receptors in these patients. Here, NR4A1 is linked to neoplasm.