Moreover, breast cancer cell lines released EVs were identified to be rich in mir-130a, which contributes to tumorigenesis of cancer by regulating TGB-β/Smad signaling (146), mir-106b that promotes breast cancer invasion and metastasis by targeting BRMS1 and RB (147), miR-210 that promotes angiogenesis and metastasis in vivo (148), and several others miRNAs (149). This evidence concerns the gene RB1 and breast cancer.