SPRY2 and neoplasm: miR-21 is highly enriched in EVs and is considered to be an oncogene, as it promotes tumor cell proliferation, migration, and invasiveness by targeting a number of tumor-suppressor genes, such as various components of the p53 network (43), PTEN (44), and antagonists of the RAS pathway PDCD4, BTG2, SPRY2, and others (45–47).