Furthermore, Tsuboi et al. described a new mechanism of tumor escape involving Gal-3 and NK cells in bladder cancer (83); the authors demonstrated that overexpression of core 2 β(1→6)-N-acetylglucosaminyl transferase 1 (C2GnT1), a glycosyltransferase responsible of generating branched core-2 O-glycans that can be elongated with poly-N-acetyllactosamine (LacNAc) sequences, negatively controls the activity of tumor-associated major histocompatibility complex class I-related chain A (MICA). The gene discussed is LGALS3; the disease is neoplasm.