Long term excessive iodine intake increases the activity of Thyroid Stimulating Hormone (TSH) and reduces thyroid hormone production, through loss of the "escape" phenomenon after the Wolff-Chaikoff effect (inhibits organification in the thyroid gland, the formation of thyroid hormones inside the thyroid follicle, and the release of thyroid hormones into the bloodstream) resulting in low thyroid hormone levels, or hypothyroidism in fetuses and newborns [9]. This evidence concerns the gene TG and hypothyroidism.