MYO5B and microvillus inclusion disease: For instance, an earlier study on MVID—a form of congenital enteropathy, indicates that the expression of MYO5B-P660L (an MVID-associated mutation found within Navajo populations) in patients with MVID resulted in global changes in polarity at the villus tips that could lead to a number of complications including aberrant junctions, and losses in transcellular ion transport pathways (Knowles et al., 2014).