TP53 and small cell lung carcinoma: In addition, in another study of 110 SCC a frequency of TP53 mutations on 57% was found (Scoccianti et al., 2012), and in a meta-study of SCLC and NSCLC, the frequency of TP53 mutations was 40% among smokers (n = 1232), which is more in line with our findings (Liu et al., 2014).