c-Myc and SIRT1 expression levels were inversely correlated with miR-494 expression in pancreatic cancer tissues due to direct interaction with the 3′UTR with the mRNA transcripts of both c-Myc and SIRT1, and restoring miR-494 sensitized the cells to chemotherapy (Liu Y. et al., 2015). This evidence concerns the gene SIRT1 and familial pancreatic carcinoma.