SET and MYND domain-containing protein 3 (SMYD3) is a H3K4-specific dimethyltransferase and trimethyltransferase that plays an important role in oncogenesis, as noted by its upregulation in colorectal carcinoma, hepatocellular carcinoma, and breast cancer (Tsuge et al., 2005; Hammamoto et al., 2006). Here, SMYD3 is linked to hepatocellular carcinoma.