If the positive correlation between Fru-His in the fresh fruit and in the processed tomato will be demonstrated, the significant differences in Fru-His detected in the material studied here could be a basis to obtain fortified tomatoes as a consequence of the antioxidant potential of Fru-His and the inhibitory activity of Fru-His/lycopene against prostate cancer cell proliferation (Mossine et al., 2008). This evidence concerns the gene ZBTB22 and Familial prostate cancer.