Furthermore, many other genes involved in function and Treg lineage were downregulated (TRAF6, STAT5, ETS-1, LEF-1) (148–151) but also Treg function inhibitor genes were upregulated after infection (LTA; IL-18RAP, BCL6, IL-7) (152–155), probably contributing to the HIV-dependent Treg impairment. The gene discussed is STAT5A; the disease is infection.