Since Foxp3 has a deep influence on Treg-associated genes expression (62) and that Foxp3 expression is highly modified during HIV infection (36), we can assume that such dysregulation in the production of cytokines may affect Treg function, since this dysregulation correlates with Treg switch to a T helper type 2 cytokine profile that may contribute to the hyperactivation shown in HIV patients. This evidence concerns the gene FOXP3 and HIV infectious disease.