Although the chemokines have direct antiviral activities in the recruitment of inflammatory cells to the site of infection to kill the virus or virus-infected cells (Melchjorsen et al., 2003), overexpression of CCL5 (RANTES) or CXCL10 (IP-10) increased RABV pathogenicity by causing neurological diseases, which is due to the excessive infiltration and accumulation of the inflammatory cells in the CNS (Zhao et al., 2009). This evidence concerns the gene CCL5 and infection.