Notably, the IFN-β and IRF-7 were up-regulated earlier at day 4 after HEP-Flury infection but not in CVS-11 infection, and IFN-γ was significantly elevated in the HEP-Flury infected mouse brains than the CVS-11 infected mouse brains after 10 dpi (Figure 5B). Here, IFNB1 is linked to infection.