The proinflammatory chemokines in both the families C-C and C-X-C, including CCL2 (MCP), CCL3 (MIP-1α), CCL4 (MIP-1β), CCL7 (MCP-3), CXCL1 (MIP-2α), CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (IP-9) were all up-regulated with both CVS-11 and HEP-Flury infections and reached peak levels at 10 dpi, some even increased more than 1000-fold (Figures 5C,D). Here, CXCL10 is linked to infection.