CXCL10 and nervous system disorder: Although the chemokines have direct antiviral activities in the recruitment of inflammatory cells to the site of infection to kill the virus or virus-infected cells (Melchjorsen et al., 2003), overexpression of CCL5 (RANTES) or CXCL10 (IP-10) increased RABV pathogenicity by causing neurological diseases, which is due to the excessive infiltration and accumulation of the inflammatory cells in the CNS (Zhao et al., 2009).