CD4 and disease arising from reactivation of latent virus: Since cIL-10 is one of the most abundant cytokines in the secretome produced by cells latently infected with HCMV, and believed to create an immune suppressive environment and to suppress apoptosis (Mason et al., 2012; Poole and Sinclair, 2015), LAcmvIL-10 is thought to reduce the ability of CD4+ cells to recognize HCMV-infected cells during latent infection (Mason et al., 2012; Poole and Sinclair, 2015).