In this scenario, the increased secretion of IL-8 may stimulate the recruitment and trafficking of leukocytes to the site of infection within the retina; on the other hand, the decrease in CCL2/MCP-1 and CCL7/MCP-3 levels in the extracellular environment may limit the migration of leukocytes, thus contributing to the virus escape of the host innate immune response (Momma et al., 2003). The gene discussed is CXCL8; the disease is infection.