Most LRRK2 G2019S PD cases have the typical pattern of brainstem pathology with Lewy bodies with variable cortical involvement, but Lewy bodies are not a universal finding, and are present in less than half of those with LRRK2 mutations other than G2019S (24), in keeping with the more benign phenotype when compared to SNCA-associated PD. The gene discussed is LRRK2; the disease is Parkinson disease.