APOE and Parkinson disease: A large meta-analysis of over 4000 cases and 10,000 controls has suggested an over-representation of APOE-ɛ2 carriers among PD patients compared to controls, although the odds ratio was very modest at 1.16 (95% CI 1.03–1.31) (84), and association between APOE and PD risk has not been replicated in further large scale genetic association studies (87) or genome-wide association studies in PD.