In addition, when non-synonimous genetic variants located at the intracellular tail encoded by exon 7 of the CASR gene were analyzed in a cohort of neuroblastoma patients, a haplotype including a polymorphism considered to mildly reduce CaSR activity (Heath et al., 1996; Cole et al., 1999; Scillitani et al., 2004, 2007; Hu and Spiegel, 2007; Vezzoli et al., 2007; Yun et al., 2007) was associated with poor outcome (Masvidal et al., 2013). This evidence concerns the gene CASR and neuroblastoma.