ID2 is a helix-loop-helix transcription factor controlled by MYC proteins that blocks differentiation and promotes cell proliferation (Lasorella et al., 2000), and MYB is a transcription factor that cooperates with MYCN in cell cycle regulation of MYCN-amplified neuroblastomas (Gualdrini et al., 2010). Here, ID2 is linked to neuroblastoma.