Association of MYCN amplification and epigenetic silencing of several genes in neuroblastoma had been previously reported (Alaminos et al., 2004), although the underlying mechanisms are still under investigation (Perini et al., 2005; Hervouet et al., 2009; Murphy et al., 2009, 2011; He et al., 2013). Here, MYCN is linked to neuroblastoma.