PI3K is a family of lipid kinases known to phosphorylate PtdIns(4,5)P2 at position 3 resulting in PtdIns(3,4,5)P3. PtdIns(3,4,5)P3 is a second messenger involved in regulating cell survival, proliferation, and growth, and its enhancement frequently leads to cancers (Engelman et al., 2006; Yuan and Cantley, 2008). This evidence concerns the gene PIK3CA and cancer.