FMO5 and pulmonary arterial hypertension: Our observations regarding the importance of ROS derived from NADPH oxidase are consistent with those in a study of CIH-induced cardiorespiratory changes including the increased occurrence of apnea during sleep in rats (Edge et al., 2012), augmentation of the chemoreflex control of sympathetic activity in rats (Marcus et al., 2010), pulmonary hypertension in mice (Nisbet et al., 2009), sensory plasticity of the carotid body in rats and mice (Peng et al., 2009), and arterial hypertension in mice (Schulz et al., 2014).