The primary outcome assessed change from baseline in the PANSS total score in an overall schizophrenia population and a predefined subpopulation which excluded non-Hispanic white patients with the A/A genotype at the serotonin 2A receptor (5-HT2AR) single nucleotide polymorphism rs7330461 (Downing et al., 2014). Here, HTR2A is linked to schizophrenia.