SIRT1 and cardiovascular disorder: SIRT1-dependent activation mitobiogenesis as an adaptive reaction to various pathophysiological factors, such as starvation, disrupted glucose homeostasis, oxidative stress, aging and cardiovascular disease (Chen et al., 2005; Hsu et al., 2010; Iwabu et al., 2010; Nadtochiy et al., 2011a,b; Nogueiras et al., 2012; Lu et al., 2014; Yoon et al., 2014).