Recent evidences demonstrate that tubulin-targeting drugs (docetaxel) cause cytoplasmic AR sequestration ex vivo (Jiang and Huang, 2010; Zhu et al., 2010; Buonerba et al., 2011; Mezynski et al., 2012) and in circulating tumor cells (Buonerba et al., 2011), significant down-regulation of AR and PSA expression, and nuclear accumulation of the fork head transcription factor family member FOXO1. This evidence concerns the gene AR and neoplasm.