Docetaxel caused cytoplasmic AR sequestration ex vivo (Jiang and Huang, 2010; Zhu et al., 2010; Buonerba et al., 2011; Mezynski et al., 2012) and in circulating tumor cells (Darshan et al., 2011) with significant down-regulation of AR and PSA expressions, so the PSA value seemed not to be useful in CRPC AR-independent (Caraglia et al., 2005; Kuroda et al., 2009; Loriot et al., 2013; Caffo et al., 2015). This evidence concerns the gene AR and neoplasm.