SCN2A and Benign familial neonatal-infantile seizures: Dominant mutations in SCN2A encoding Nav1.2 channels cause Benign Familial Neonatal-Infantile Seizures (BFNIS; prevalence: <1/1000,000), a mild seizure syndrome that responds positively to treatment with anti-epileptic drugs (AEDs), and generally remits by 1 year of age (Berkovic et al., 2004).