Patients affected by episodic ataxia type 1, a form of episodic ataxia with myokymia (see below) caused by loss-of-function mutations in KCN1A (coding for Kv1.1 channel), often report abnormal EEGs, and several animal models carrying kcna1 gene defects show an increased susceptibility to seizures (Smart et al., 1998). Here, KCNA1 is linked to hereditary continuous muscle fiber activity.