Some studies reported polymorphisms or mutations in the chloride channel genes CLCN2 (ClC-2) and CLCN1 (ClC-1) in epileptic patients but the involvement of these channels in epilepsy remains controversial (Saint-Martin et al., 2009; Niemeyer et al., 2010; Chen et al., 2013). The gene discussed is CLCN2; the disease is epilepsy.