CLCN5 and Dent disease: Mutations in CLCN5 gene cause a subtype of Dent’s disease type 1 (prevalence: 250 reported families), a renal tubular disorders characterized by low molecular weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure (Lloyd et al., 1997; Hodgin et al., 2008).