RELN and autism: This view is supported not only by animal studies involving heterozygous reeler mice, which model some behavioral dysfunction similar to schizophrenia (Costa et al., 2002), but also by recent human genetic studies identifying heterozygous REELIN mutations in lateral temporal epilepsy (Dazzo et al., 2015), and pointing to REELIN as a risk factor in autism (De Rubeis et al., 2014).