RAGE, a member of immunoglobulin superfamily and a multiligand cell surface receptor, binds to AGEs, such as carboxymethyllysine (CML), and interacts with a number of other molecules such as S100/calgranulin family members, High Mobility Group Box-1 (HMGB1), and molecules that are prone to aggregation and post translational modifications (Ding and Keller, 2005), such as amyloid-β-peptide, linked to Alzheimer's disease (AD) and neurodegeneration (Chen et al., 2007; Schmidt et al., 2009). Here, HMGB1 is linked to Alzheimer disease.