ADSL and hyperinsulinemic hypoglycemia, familial, 4: Other disorders of energy metabolism are associated with ASD and epilepsy, including disorders of creatine metabolism (Póo-Argúelles et al., 2006; Longo et al., 2011) and adenylosuccinate lyase deficiency (Spiegel et al., 2006; Jurecka et al., 2008).