When activated, this pathway protected organs, including heart, from the consequences of the ischemic injury [89, 90, 100, 101], decreased levels of CCL2 and LIX after reperfusion injury [88], and downregulated the expression of CCL2, CCL4, CCL5, CCR1, CCR2, and CCR5 in murine autoimmune myocarditis [102]. The gene discussed is CCL2; the disease is autoimmune myocarditis.