On the basis of the finding that EGFR is a direct target of miR‐134 and that the overexpression of miR‐134 can inhibit EGFR expression in NSCLC cells, we next investigated whether miR‐134 could suppress EGFR‐associated signaling by down‐regulating EGFR expression. This evidence concerns the gene EGFR and non-small cell lung carcinoma.