In further stratified analyses by age at a cut‐off value of 55 years (median), the allelic association with breast cancer risk was strikingly significant for RAGE gene rs1800624 polymorphism among subjects aged <55 years (P = 0.005) and for HMGB1 gene rs2249825 polymorphism among subjects aged ≥55 years (P = 0.007; Table S1). The gene discussed is HMGB1; the disease is breast cancer.