In RAGE gene, when compared with the reference haplotype T‐T‐G (alleles in order of rs1800625, rs18006024, rs2070600 polymorphisms), two haplotypes, C‐T‐A and C‐A‐G, were over‐represented in patients, and were significantly associated with an increased risk of breast cancer even after adjusting for age and age of menarche (adjusted OR = 2.72 and 10.35; 95% CI: 1.20–6.18 and 1.58–67.80; P = 0.017 and 0.015). Here, AGER is linked to breast carcinoma.