These two SNPs were not genotyped in iCOGS, but their imputed results (r2 > 0.94) again revealed significant associations (P = 0.021) with breast cancer risk in BRCA1 mutation carriers, with effect estimations similar to rs884205: rs2957137 HR = 1.079, rs3018354 HR = 1.052. The gene discussed is BRCA1; the disease is breast cancer.