Among others, these included thyroxine binding globulin, transthyretin, AXL receptor tyrosine kinase, ferritin, serum amyloid component P-component, HER-2, osteopontin, and immunoglobulin M. These could play a role in the increased prevalence of many conditions after menopause, including cardiovascular disease49, osteoporosis50, metabolic syndrome51, Alzheimer’s disease, and late-onset schizophrenia52. Here, SPP1 is linked to Alzheimer disease.