In patients suffering from CAD [69,70,72] and congestive heart failure [48] (Table 5), daily ingestion of flavanol-rich chocolate [48,69] or cocoa [70,72] for 28–42 days did not change CRP [48,69,70], P-selectin, E-selectin, ICAM-1, or VCAM-1 [69]. The gene discussed is SELE; the disease is congestive heart failure.