Mechanisms accounting for this relationship may be, for example, mechanical load that in turn stimulates bone formation [28], androgens-to-estrogens conversion in adipose tissue, lower serum levels of Sex Hormone Binding Globulin (SHBG) [29], increased serum leptin levels [30], increased insulin growth factor production and hyperinsulinemia [31]. The gene discussed is SHBG; the disease is Hyperinsulinemia.