On microvascular scale, Hadjadj et al. [9] conducted a large, family-based, case-control study in 3 different European populations and they discovered that five ACE polymorphisms (rs1800764-C, rs4311-T, Insertion/deletion (I/D or rs1799752)-D, rs4366-G, and rs12449782-G alleles) had statistically significant association with increased risk of diabetic nephropathy. This evidence concerns the gene ACE and diabetic kidney disease.