MiR-192 overexpression diminished the expression of p21Cip1, p27Kip1, p107, p130 and retinoblastoma-1 tumor suppressor protein (Rb1) and increased the expression of cyclin D1, cyclin D2, CDK4, CDC2, and SKP-2 in both pancreatic cancer tissues and cell lines [41,132]. This evidence concerns the gene CDKN1B and familial pancreatic carcinoma.