MiR-221 is vital for the platelet-derived growth factor (PDGF)-mediated epithelial-mesenchymal transition (EMT) phenotype, migration and growth of pancreatic cancer cells by down-regulating tricho-rhino phalangeal syndrome type 1 (TRPS1) and p27 [31]. This evidence concerns the gene CDKN1B and familial pancreatic carcinoma.