This inflammation does not, however, seem to contribute to epidermal malignancy, as epidermal aggregates of unaltered numbers and sizes were also obtained in psoriasis mutants after ablation of the myeloid lineage by pu.1 antisense morpholino oligonucleotide (MO) injection (Carney et al., 2007) (Figure 2—figure supplement 2a–e). Here, SPI1 is linked to psoriasis.