By contrast, the lateral regions of peridermal cells were less organized (Figure 6d,e), and aberrant gaps were observed between peridermal cells and underlying basal keratinocytes (Figure 6b–f), Furthermore, the membranous localization of Cdh1 and Lgl2 proteins was strongly diminished in both the peridermal and basal cells of psoriasis mutants, independent of whether they had been incubated in hypotonic or isotonic medium (Figure 7a–h). Here, CDH1 is linked to psoriasis.