AKT1 and breast cancer: Furthermore, PI3K, AKT and NFκB mediate the tumorigenic effects of different cytokines in cultured prostate, gastric and leukemic cancer cells (Dilly et al., 2013; Kang et al., 2011; Wang et al., 2011), while mTORC1 controls NFκB activity downstream of pAKT in prostate and breast cancer cells (Dan et al., 2008; Davis et al., 2014).