CDH1 and psoriasis: Here, we report that a loss-of-function mutation in the β-subunit Atp1b1a causes epidermal malignancy in zebrafish psoriasis mutant embryos (Webb et al., 2008), correlated with reduced E-cadherin levels and a genetic interaction with the formerly described epithelial polarity regulator and tumor suppressor Lgl2 (Sonawane et al., 2005; Reischauer et al., 2009).