Similarly, we found no difference in the expression of BiP and CANX between non-tumor organoids overexpressing AGR2 (HBEC-AGR2) or not (HBEC-EV) (Figure 5F and Figure 5-—figure supplement 1B) indicating that the secretory pathway was not altered upon changes in AGR2 expression. This evidence concerns the gene HSPA5 and neoplasm.