APC and colorectal cancer: COX2 expression is elevated in polyps of ApcMin/+ mice34 and in human colorectal cancer.63 ApcMin is defective in regulation of COX2 via inhibition of CtBP1.36 COX2 inhibitors are well documented by epidemiological studies to delay colon carcinogenesis.64, 65 Thus, our data indicates that TSP1, Apc and dietary fat are convergent regulators of PGE2 levels.