Autophagy is demonstrated to be activated in murine intestinal epithelium and human colon cancer.57, 58 In an ApcMin/+ model, deletion of autophagy-related protein-7 (Atg7) led to AMPK activation and reduction in carcinogenesis.57 Loss of the TSP1/CD47 signaling axis is implicated in the activation autophagy in non-transformed tissue.59 Although the role of TSP1/CD47 signaling in regulation of autophagy in cancer is unknown, circulating levels of TSP1 may inhibit this pathway to ameliorate cancer development. The gene discussed is CD47; the disease is cancer.