THBS1 and adenoma: Notably, 10 of the affected amino acids coincide with amino acids that, when quantified in plasma of ApcMin/+ mice fed high- versus low-fat diet, significantly correlated with adenoma numbers in those mice.29 Therefore, we predict that TSP1-dependent changes in liver amino-acid metabolism contribute to the effects of TSP1 to modulate the effect of dietary fat on intestinal carcinogenesis.