During starvation, ketone bodies are used as an energy source, and the decreased use of glucose by peripheral organs such as the liver suggest an increased dependence on fat as an energy source.56 Since ApcMin/+:Thbs1−/− have increased tumor multiplicity, glucose utilization may shift toward tumors while leaving peripheral organs to rely on fatty acid and ketone body formation to maintain energy levels. The gene discussed is THBS1; the disease is neoplasm.