THBS1 and adenoma: ApcMin/+:Thbs1−/− mice that were fed a low-fat diet had a 40% (P<0.03) increase in adenoma formation in their small intestine (Figures 1c and e) and a 52% (P<0.02) increase in the large intestine when compared with ApcMin/+ mice fed the same diet (Figures 1d and f).