THBS1 and obesity due to melanocortin 4 receptor deficiency: 1-Methylnicotinamide is a potent anti-inflammatory and antithrombotic molecule, and its activity was blocked by a COX2 inhibitor.40, 41 Although expression of its biosynthetic enzyme nicotinamide-N-methyltransferase was induced in some obesity models,42 1-methylnicotinamide levels in WT and Thbs1−/− liver were suppressed by high fat intake and were basally lower in ApcMin/+: mice (Figure 4g).