Several studies have demonstrated that loss or inhibition of TSP1 expression increases colon carcinogenesis and malignant progression.49, 50, 51, 52 Decreased TSP1 expression in adenomas of ApcMin/+ mice was associated with a reduced apoptotic index, increase in proliferation and differential patterns of vessel density.15ApcMin/+:Thbs1−/− showed increased vascularization in pre-malignant intestinal tissue but no significant differences in vascularization between adenomas and carcinomas between ApcMin/+ and ApcMin/+:Thbs1−/−. This evidence concerns the gene THBS1 and adenoma.