AAA+ family proteins have critical roles in diverse biological processes via their ATPase-driven remodeling of macromolecular complexes.7, 8, 9 Several researchers have identified that ANCCA/PRO2000 functionally controls the crucial regulators of cell proliferation and survival pathways including E2F1/3, EZH2, B-Myb and MYC in breast cancer, prostate cancer, lung adenocarcinoma and endometrial cancer. The gene discussed is ATAD2; the disease is breast cancer.