ATAD2 and hepatocellular carcinoma: Previous work from our lab identified that ANCCA/PRO2000 as a proliferation-associated protein predicts poor prognosis in patients with HCC.17 Recent studies also suggested that ANCCA/PRO2000 exerts strong oncogenic function based on the investigations on cell proliferation, migration and invasion in HCC.18, 19 However, to date, downstream targets and molecular mechanisms related to its oncogenic activity have not been properly explored.