ANCCA/PRO2000 is always overexpressed in cancer cells and correlates with poor overall survival and disease recurrence.6, 10, 11, 12, 13, 14, 15, 16 We previously identified that ANCCA/PRO2000 functions as an important proliferation-associated protein and a predictor of poor prognosis in HCC.17 Studies from others also disclose that ANCCA/PRO2000 with a high expression in HCC could regulate the proliferative, invasive and migratory capacity of HCC cells.18, 19 However, the molecular mechanism of ANCCA/PRO2000 in the hepatocarcinogenesis and progression remains unclear yet. The gene discussed is ATAD2; the disease is hepatocellular carcinoma.