Overstimulation of PI3K signaling may promote resistance to clinical therapies, which has sparked interest to improve current therapies or find new drug targets.60, 61, 62, 63 Notably, EGFR mutations, which are also common in human cancers, can stimulate PI3K signaling directly by Ras-independent pathways,64, 65, 66 which adds to the importance of misregulated PI3K signaling in oncogenesis. Here, EGFR is linked to cancer.