PTEN, EGFR, TP53, CDKN2A, CDK4 and LOH are several frequently mutated genes.24 PTEN mutations are frequently involved with this aggressive cancer, our initial aim was to decipher the regulation of mTORC2 with respect to PTEN wild-type (PTENwt) vs mutated conditions (PTENmu; Figure 1a). Here, PTEN is linked to cancer.