To correlate our observation, we found that mahanine inhibited AKT in two PTENmu prostate cancer cells.26, 32 Mahanine, in contrary, prevented palmitate-induced inhibition of the insulin-stimulated phosphorylation of AKT in a PTENwt cell.48 According to our hypothesis and findings, in PTENmu prostate cancer cells, mahanine might inhibit AKT completely by suppressing both mTORC1/2. Here, INS is linked to Familial prostate cancer.