mTORC2 activity is required for generation of PTEN deletion-induced prostate cancer.36 EGFRvIII-mediated activation of mTORC2 was reversed by PTEN activity.37 A correlation between PTEN and Rictor was also reported in leukemogenesis.38 Here we showed that PTENmu cells have higher mTORC2 formation and downstream signaling than PTENwt cells as evidenced by enhanced mTOR Ser2481, AKT Ser473 and GSK3β Ser9 phosphorylations. This evidence concerns the gene PTEN and Familial prostate cancer.