RPS6KB1 and cancer: mTORC1 promotes protein translation through activation of S6K1, inhibition of 4E-BP1 and enhancement of RNA translation via S6 ribosomal protein.2, 14 mTORC2 can specifically phosphorylate AKT at the Ser473 and take part in cell proliferation, regulation and cytoskeletal reorganization.15, 16 Rapamycin and its analogs (rapalogs) are used for treatment of cancers as mTORC1 inhibitors.