These differing results between ROR1 and ROR2 after silencing and overexpression suggests that they may facilitate alternative signalling pathways as discussed previously.27 Recently, it has been found that ROR1 is critical in the structure and formation of caveolae36 and is a target for the frequently amplified NKX2-1 gene in lung adenocarcinoma.37 Interestingly, its significance as a scaffold protein for a number of other RTKs was found in sustaining caveolae formation and prosurvival signalling. This evidence concerns the gene ROR1 and lung adenocarcinoma.