Recent studies demonstrate that the novel Wnt receptors ROR1 and ROR2 correlate with worse prognosis and drive EMT in a variety of tumour types including breast cancer, cervical cancer and melanoma.15, 23, 24, 25, 26 Our laboratory reported that upregulation of Wnt5a in epithelial ovarian cancer regulates EMT10 and confirmed that the novel Wnt5a receptor, ROR2, is also upregulated in a patient cohort of ovarian cancer. This evidence concerns the gene ROR1 and ovarian cancer.