The SNPs in or near the promoter region of the high temperature required factor A1 (HTRA1) or age-related maculopathy susceptibility protein 2 (ARMS2) genes on chromosome 10 include rs11200638 rs10490924, rs11200638 and rs2293870 are the strongest genetic contributor to wet AMD and these result in increased production of VEGF in the retina. This evidence concerns the gene VEGFA and wet macular degeneration.