ARMS2 and wet macular degeneration: The SNPs in or near the promoter region of the high temperature required factor A1 (HTRA1) or age-related maculopathy susceptibility protein 2 (ARMS2) genes on chromosome 10 include rs11200638 rs10490924, rs11200638 and rs2293870 are the strongest genetic contributor to wet AMD and these result in increased production of VEGF in the retina.