APOE and Alzheimer disease: Cox regression model revealed that cognitively healthy individuals with low baseline Aβ42 levels had an increased risk of subsequent AD or DLB with an HR of 11.9 (95% CI, 1.5–94.2; P < .05) for each SD decrease of CSF Aβ42 levels when adjusted for age, gender, presence of APOE ε4 allele, and baseline delayed word recall.