As shown in Table 1, miR‐497 was expressed at prominently lower levels in HCC patients with high alpha‐fetoprotein (AFP) level (P = 0.002), large tumor size (P = 0.011), high Edmondson–Steiner grading (P = 0.016), and advanced TNM tumor stage (P = 0.004). The gene discussed is AFP; the disease is neoplasm.