GDF15 and chronic obstructive pulmonary disease: Interestingly, we have also shown that miR‐1 is suppressed in the muscle of patients with COPD and that quadriceps expression of both miR‐1 and miR‐499 is directly correlated with FFMI.27 It is therefore possible that in COPD, GDF‐15 suppresses the expression of these miRNAs to contribute to the reduction in muscle size.