1. Explore the relationship between the immune system and CAA-ICH by using    genomic, neuropathological, and immunological studies2. Explore the role of oxidative stress, and in particular antioxidant enzymes such    as SOD, in CAA-ICH using mouse model experiments and longitudinal human    biomarker studies3. Explore the role of vascular risk factors such as blood pressure in ICH in DS by    using population-based epidemiological studies. This evidence concerns the gene SOD1 and Dravet syndrome.