1. Establish the relationship between Aβ 40/Aβ 42 ratios and development of CAA    and ICH in DS by using neuropathological studies2. Experimental studies of Aβ clearance by endocytosis, enzymatic degradation,    and removal through the blood-brain barrier by using animal and cellular models3. Compare DS and dup-APP by using neuropathological and cellular studies and    animal models. The gene discussed is APP; the disease is Dravet syndrome.