For example, comprehensive analyses of transcriptome and epigenome data obtained from adult T cell leukemia (ATL) cell lines, normal CD4+T cells, human T-lymphotropic virus type 1 (HTLV-1)-immortalized and transformed T cells show the importance of increased, NF-κB dependent expression of EZH2 (both RelA and RelB were shown to be bound to EZH2 promoter) which further activates NF-κB through silencing of microRNA (miR)-31. The gene discussed is EZH2; the disease is adult T-cell leukemia/lymphoma.